TGF-β Signaling: New Insights Into Aortic Aneurysms
نویسنده
چکیده
Article history: Received 28 September 2016 Accepted 28 September 2016 Available online 3 October 2016 The canonical pathway influences the phosphorylation of SMADs which can modulate gene expression patterns at both preand posttranscription within the cell. This pathway typically inhibits the proliferation of cells, however under SMAD3 deficiency, VSMCs were shown to have increased rates of proliferation (van der Pluijm et al., 2016). This further indicates that patients with SMAD3 mutations may
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2016